Feeding and activating the endogenous antioxidant defenses

Impryl is the benchmark of the antioxidants support. According to the new strategy, instead of using antioxidant substances, that act only on a limited number of sensitive pathways and that may generate negative counter effects, Impryl leverage on the physiologic antioxidant system to achieve a better oxy-redox balance within the control of the natural cellular homeostasis. This approach is resulting in clinical improvements that appeared impossible by using traditional antioxidant molecules. In addition Impryl contains only substances normally present in the diet for a easy and safe use with no limits of duration.

Its formula contains all the substances required for the activation of antioxidant defenses in the absence of any substance with direct antioxidant activity. Moreover, it supplies the substances capable of compensating for the possible presence of the most common pathological variants of metabolic enzymes, in particular:

• Folic acid in its methylated, active form (methylfolate) to compensate for a possible defect of the enzyme MTHFR (Methylene-Tetra-Hydro-Folate-Reductase)

• Vitamin B12in its methylated, active form (methylcobalamine) to compensate for a possible defect of the enzyme MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase)

• Betaine (trimethyl glycine) to compensate for a possible defect of the enzyme CHDH (choline-dehydrogenase)

• Cysteine donor (cystine) to compensate for a possible defect of the enzyme CBS (cystathionine beta synthetase)

Thus, Impryl provides the maximum possible support to the antioxidant defenses and will be active in all subjects independently of their genetic substrate.

Impryl is completely free from direct antioxidants and works by inducing the endogenous cellular antioxidant defenses that, subject to the regulation of cellular homeostasis, will act as far as necessary and useful to the cell.

IMPLYL BENEFITS EVERYBODY

Impryl was conceived as a nutritional intervention to support the health of all and its use does not necessarily imply the presence of a condition to be corrected. In addition, the modern lifestyle and the increasing environmental pollution expose all of us to excessive oxidative assaults that should be duly balanced, possibly before the same hesitate in clinical damages.

Nevertheless, the metabolic normalization obtained with Impryl is particularly useful in case of malfunctions that have a clear metabolic basis and / or deficiency. For example, Impryl, assumed continuously or in cycles, is recommended for those who have high levels of circulating homocysteine and / or high risk of cardiovascular and neurodegenerative disease.

Thanks to the content in methylfolate and methylcobalamine, that compensate the common MTHFR and MTRR genetic polymorphism, Impryl may benefit everybody with no need for genetic testing.

PREGNANCY SUPPORT

The remarkable effectiveness of the antioxidant activation on the one hand and the respect for the metabolic physiology on the other, make Impryl the ideal support for reproduction. Gametogenesis is, among the physiological functions, the most sensitive to a perfect metabolic balance. This is currently defined as pre-conceptional support, i.e. a supplementation of both partners from at least three months before conception. The positive effects will concern not only the chances of conceiving but also the probability of having a serene pregnancy and a healthy baby. For comprehensive information see the preconception care advices from the World Health Organization (WHO).

Thereafter, once the pregnancy occurs, research has definitely confirmed the need for a pregnancy support with folic acid to prevent the Neural Tube Defects (NTDs) including spina bifida. More recent studies have demonstrated a similar protective effect on the onset of Autism Spectrum Disorders (ASD), which are a modern health alert, likely related to the environmental toxicity. Studies also indicate that a multivitamin support is preferable to folic acid alone. In addition, supplements providing folic acid in the form of methylfolate are better appropriate for subjects carryin a defective MTHFR gene. Final demonstrations will require many years but it is already clear that a supplementation covering all metabolic problems is preferable. Impryl is at present the most complete support for pregnancy.

MENOPAUSE

The remarkable effectiveness of the antioxidant activation on the one hand and the respect for the metabolic physiology on the other, make Impryl the ideal support for reproduction. Gametogenesis is, among the physiological functions, the most sensitive to a perfect metabolic balance. This is currently defined as pre-conceptional support, i.e. a supplementation of both partners from at least three months before conception. The positive effects will concern not only the chances of conceiving but also the probability of having a serene pregnancy and a healthy baby. For comprehensive information see the preconception care advices from the World Health Organization (WHO).

Thereafter, once the pregnancy occurs, research has definitely confirmed the need for a pregnancy support with folic acid to prevent the Neural Tube Defects (NTDs) including spina bifida. More recent studies have demonstrated a similar protective effect on the onset of Autism Spectrum Disorders (ASD), which are a modern health alert, likely related to the environmental toxicity. Studies also indicate that a multivitamin support is preferable to folic acid alone. In addition, supplements providing folic acid in the form of methylfolate are better appropriate for subjects carryin a defective MTHFR gene. Final demonstrations will require many years but it is already clear that a supplementation covering all metabolic problems is preferable. Impryl is at present the most complete support for pregnancy.

POLYCYSTIC OVARY SYNDROME (PCOS)

The Polycystic Ovary Syndrome (PCOS) ia a very common condition characterised by ovarian cysts, hyperandrogenism, impaired glucose metabolism (sub-clinical diabetes) and ovulatory disturbances and may associate to sub-fertility.

A targeted antioxidant support with Impryl has the potential to block this process restoring a normal metabolic and endocrine function. In some cases Impryl has favoured a fast and complete regression of the syndrome.

It is to be noted that PCOS ladies are at a higher risk to carry a defective variant of the MTHFR gene and will benefit from the content in methylfolate of Impryl.