INDICATION

Significantly increases skin moisturisation.

PRESENTATION

White fluid.

FORMULATION

Lotion with 42% occlusive ingredients and 14% humectants.

INGREDIENTS

Aqua, Dimethicone, Isopropyl Palmitate, Ethylhexyl Cocoate, Isododecane, Isopropyl Myristate, Urea, Polyglyceryl-2 Dipolyhydroxystearate, Glycerin, Pentylene Glycol, Dicaprylyl Carbonate, Polyglyceryl-3 Diisostearate, Sodium Lactate, Dipentaerythrityl Hexacaprylate / Hexacaprate, Gluconolactone, Rosa Canina Fruit Oil, Simmondsia Chinensis Seed Oil, Calendula Officinalis Extract, Butyrospermum Parkii Oil, Helianthus Annuus Seed Oil, Glycine Soja Oil, Isostearyl Isostearate, Bisabolol, Octyldodecyl PCA, Retinyl Palmitate, Tocopheryl Acetate, Linoleic Acid, Linolenic Acid, Tocopherol, Sodium PCA, Sodium Hyaluronate, Lactic Acid, Stearalkonium Hectorite, Propylene Carbonate.

SAFETY ASSESSMENT

Bio‑Oil® Body Lotion has undergone a safety assessment by a qualified toxicologist and has been classified as safe for its intended use by adults, including pregnant and lactating women, and children over three years old.

DRY SKIN CLINICAL TRIAL

Trial centre

Complife Italia S.r.l, Italy.

Objective

A clinical evaluation to test the efficacy of Bio‑Oil® Body Lotion in improving skin moisturisation.

Sample

Subjects: 30 healthy female participants with Fitzpatrick skin types II-V and clinically showing dry / very dry skin at the level of the outer lower legs. Test site: test product applied to an outer, lower leg of all subjects. Age of participants: 25–65.

Methodology

Split body, evaluator-blinded, randomised and controlled clinical-instrumental study. Participants washed their legs with soap to induce dry skin over a 7-day period. Baseline clinical and instrumental evaluations were taken. Bio‑Oil® Body Lotion was applied twice daily for 28 days to the assigned lower lateral leg, the opposite leg remained untreated. Clinical assessments and instrumental evaluations were conducted on days 1, 3, 6, 8, 10, 14, 21 and 28. The control untreated site was also evaluated at all time points. Subjects were clinically graded for dryness (on a scale from 0–5) by a trained visual evaluator. Quantitative measurement of skin hydration was by Corneometer. Quantitative measurement of transepidermal water loss (TEWL) as an indicator of barrier function, was by Tewameter. Additionally, a self-assessment questionnaire was completed on days 8 and 14.

Result

Compared to the untreated area, treatment with Bio‑Oil® Body Lotion resulted in a statistically significant improvement in clinical grading of dryness, Tewameter and Corneometer measurements, from as early as day 1, and at all time points. For clinical grading of dryness, statistically significant improvements were evident in 96.7% of participants from day 14 onwards, almost double the improvement noted at day 1. After 28 days of use, 100% of participants showed a significant increase in skin moisturisation, with the extent of the improvement almost 4 times that at day 1. Similarly, after 28 days of use 100% of participants showed a significant decrease in TEWL, with the extent of the improvement more than double that at day 1. These findings are supported by the results of the self-assessment questionnaire.